The action of drugs may depend on the state of the body, in particular on the pathological process, because of which they are prescribed. For example, antipyretics reduce body temperature only tramadol narcotic with its increase, but they do not lower the normal temperature.
Circadian rhythms (alternation of sleep and wakefulness) significantly affect the activity of the nervous system and endocrine glands and, accordingly, the state of other organs of tramadol and acetaminophen and systems. This, in turn, reflects the sensitivity of the body to various substances. In most cases, the most pronounced effect of drugs is noted in the period of greatest activity. Depending on the daily rhythm changes and toxicity of substances. Drugs can influence the phases and amplitude of the daily tramadol with ibuprofen rhythm. It should also be borne in mind that the result of the interaction of the drug and the human body at different times of the day may vary depending on pathological conditions and diseases.
Re-use of drugs
The increase in the effect of the drug during its repeated use is usually associated with its accumulation (cumulation) in the body. Such an accumulation of a drug for how long it takes to get out of your system for its long-term use can lead to toxic effects. To prevent them, it is necessary to gradually tramadol and acetaminophen buy online to reduce the dose, to increase the intervals between the doses of the drug or to take interruptions in treatment.
Increased action with repeated use of drugs may also be the result sensitivity enhancement organism (sensitization).
With repeated use of drugs may reduce their effectiveness. – addictive tramadol controlled substance . This may be due to a decrease in the absorption of the drug, an increase in the rate of inactivation and excretion, a decrease in the sensitivity of the receptors (substrates). When addictive, you need to increase the dose of the drug or replace it with another. However, one should take into account the 50mg tramadol that there is a cross-addiction of tramadol and acetaminophen to substances that interact with the same receptors (substrates).