To a large extent, the effect of tramadol hcl 50mg tab of drugs is determined by their dose, that is, the amount of substance intended for one dose (single dose). Not only the effectiveness of the treatment, but also the safety of the patient depends on the dose of the drug. «Poison in small doses – the best is tramadol a opiate for sale medicine; overdose – poison», ndash is a tramadol a stay buy online how long does the tramadol stay in urine; wrote in XVIII at. V. Vizburg. This is especially true in modern medical practice, when extremely active agents are used, the dose of which is measured in micrograms. Even a small overdose of such drugs can lead to serious consequences.
Individual does tramadol have tylenol in it drug sensitivity
Individual sensitivity to the drug depends on many factors: age, sex, body weight, rate of transformation in the body (metabolism), condition of the gastrointestinal tract, organs of the tramadol class blood circulation, liver, kidneys, form of the drug, route of administration, composition is tramadol a opiate and quantities of food, simultaneous use of other drugs, etc.
Drug sensitivity varies tramadol and hydrocodone depending on age. In children, this is due to the imperfections of many enzymes, kidney function, and the central nervous system. In the elderly is tramadol a opiate and old age – with a slowdown in the absorption of drugs, their transformations in the body (metabolism), lowering the rate of excretion. Sensitivity to most drugs at this age is especially increased, therefore the dose of drugs should be reduced.
In animal experiments, it has been shown that males are less sensitive to a number of substances half life of tramadol than females. Differences in metabolic transformations (metabolism) of some drugs in individuals of different sexes were also noted.
Sensitivity to drugs may be genetically determined. – lack of any enzymes or an atypical reaction to tramadol dosage for 10lb dog substances.